History

History
of the Institute of Immunology

DOMESTIC VACCINE PRODUCTION

The beginnings of domestic vaccine production date back to the period when the Croatian territories were part of the Austro-Hungarian Monarchy (1868-1918). The first compulsory smallpox vaccination against date back to 1891, and the Royal Institute for the Manufacture of Animal Vaccine Against Smallpox in Zagreb in 1893.:

“In order to meet the requirements of the 1891 Law on Smallpox Vaccination, which requires the Royal Government to distribute vaccines free of charge to administrative districts, the Royal Government established a vaccine production institute at Kukovićeva Street 27 in Zagreb. Private physician and pharmacists can also obtain fresh lymph at an appropriate price.

(Official Gazette of May 8, 1893).

The overall development path of domestic production of biological medicinal products to date has been marked by the so-called two golden periods:

Collaboration with the Rockefeller Foundation
Institute of Hygiene with the School of Public Health in Zagreb (1926)

Collaboration with the United Nations (UNICEF)
From the Institute of Hygiene in Zagreb (1947) to the Institute of Immunology in Zagreb (1961)

GOLDEN AGES

THE INSTITUTE OF HYGIENE WITH THE SCHOOL OF PUBLIC HEALTH IN ZAGREB

The School of Public Health was built with a gift from the Rockefeller Foundation and, together with the Institute of Epidemiology in Zagreb, this institution for the study, control, prevention and treatment of infectious diseases was established in 1926. On October 3, 1927 the Institute of Hygiene with the School of Public Health on Green Hill in Zagreb (the so-called White and Yellow Buildings) was officially opened, thus unifying the administrative, research, production and educational parts of the public health system in the country.

INSTITUTE OF IMMUNOLOGY IN ZAGREB

UNICEF’s intervention in the second half of the 20th century marked a turning point in our further development, from the Institute of Hygiene in Zagreb (1947), through the Central Institute of Hygiene and the Sero vaccine Institute to the Institute of Immunology in Zagreb (1961). Zagreb production successfully competed with the elite institutes of the world with its knowledge and medicinal products. New markets were conquered; there was an active participation in the training of immunological production in underdeveloped countries, scientific and technical cooperation and cooperation with other institutes in the country and institutes around the world was at the highest world level field of immunobiology.

INSTITUTE OF IMMUNOLOGY AND WHO COOPERATION

Production was accompanied by teaching work for the World Health Organization, which took place at the Institute of Immunology. The Institute was a collaborative center of the World Health Organization for research and development of immunobiological preparations as well as for the establishment of an international standard for immunobiological preparations, in which experts from the World Health Organization were recruited and educated. Scientific and technical cooperation with related domestic and foreign institutes took place continuously and successfully at all relevant levels.

INSTITUTE OF IMMUNOLOGY – A PUBLIC INSTITUTION OPERATING IN THE FIELD OF HEALTH

The founder of the Institute is the Republic of Croatia, and the founding rights and duties on behalf of the founder are performed by the Ministry of Health of the Republic of Croatia. The Institute was founded as a public health institution of strategic and general economic interest for the Republic of Croatia.

Directors of the Institute of Immunology since 2015 to the present

Godina	Ravnatelj
2019 – present	Vedran Čardžić, MD
2018	PhD. Nevenka Kovač, MD
2017	PhD. Dubravko Kičić, MBA
2017	PhD. Bojan Benko, B.Eng
2016	Lea Lupret Prugovečki, MD
2015	PhD. Nevenka Kovač, MD
2015	Mario Meštrović, B.A.

The long historical development of the Institute of Immunology in Zagreb, Republic of Croatia (production of biological medicinal products, diagnostic and other preparations for human use) chronologically includes the activities of at least the following:

1893.
Royal Institute for the Manufacture of Animal Vaccine Against Smallpox
1912
Royal Institute of Bacteriology and Hygiene
1912
1923.
Institute of Epidemiology
1926.
Institute of Hygiene with School of Public Health
1926.
1939.
Institute for the Manufacture of Medicinal Products of Biological and Chemical Composition, Banovina of Croatia
1945.
Institute of Hygiene & Institute of Epidemiology
1945.
1947.
Institute of Hygiene
1951.
Central Institute of Hygiene
Department for the Manufacture of Sera and Vaccines – since 1952
Institute for the Manufacture of Sera and Vaccines – since 1954

1951.
1956.
Sero Vaccine Institute
1961.
Institute of Immunology
1961.
1994.
Institute of Immunology, Inc.
2015.
Institute of Immunology, Public Health Institution
2015.

2015
Imunološki zavod JZU, Zgb
(4. 9. 2015. – danas)
1994
Imunološki zavod d.d., Zgb
(8.8. 1994. – danas)

1994
1961
Imunološki zavod u Zagrebu
(1961 – 1994)
1956
Serovakcinalni zavod, Zgb
(1956 – 1961)

1956
1951
Centralni higijenski zavod u Zgb
1949
Higijenski zavod u Zgb,
Odjel za proizvodnju seruma i cjepiva

1949
1945
Higijenski institut i Epidemiološki institut
1942
Zdravstveni zavod, Zgb
(05.01.1942.)

1942
1926
Higijenski zavod sa školom narodnog zdravlja, Zgb
(04.09.1926. – 05.01.1942.)
1912
Zemaljski bakteriološko-hygienski zavod, Zgb

1912
1893
Kraljevski zemaljski zavod za proizvadjanje animalnoga cjepiva, Zgb

ARCHIVE PHOTOS

Kratak pregled strateških aktivnosti 2015. – danas

Vlada Republike Hrvatske donijela je Uredbu o osnivanju Imunološkog zavoda („Narodne novine“ broj 91/2015) kao javne ustanove za obavljanje djelatnosti u području zdravstva koja je od strateškog i općeg gospodarskog interesa za Republiku Hrvatsku.

Imunološki zavod je dana 4. rujna 2015. godine registriran na Trgovačkom sudu u Zagrebu pod matičnim brojem subjekta MBS: 080987723.

Vlada Republike Hrvatske donijela je dana 27. lipnja 2019. godine Odluku o donošenju Nacionalnog plana opskrbe Republike Hrvatske lijekovima proizvedenim iz ljudske plazme 2019 – 2022 („Narodne novine“ broj 63/2019)

Program Vlade Republike Hrvatske za mandat 2020 – 2024

Vlada Republike Hrvatske donijela je dana 30. travnja 2020. godine Odluku o procjeni tržišne vrijednosti Matičnih serija virusa morbila, rubele i parotitisa i izradi studije korištenja imovine u vlasništvu Republike Hrvatske, a koju predstavljaju matični sojevi virusa koje je proizveo Imunološki zavod.

Na svojoj je sjednici održanoj 5. veljače 2021. godine Hrvatski sabor usvojio Nacionalnu razvojnu strategiju Republike Hrvatske do 2030. godine (NRS 2030) gdje je prepoznata potreba za revitalizacijom Imunološkog zavoda za samodostatnost Republike Hrvatske u proizvodnji cjepiva i krvnih pripravaka.

Nastavno na NRS unutar RH Programa Konkuretnost i kohezija 2021.-2027. (PKK 2021.-2027.) određena je sljedeća aktivnost: Ulaganje u revitalizaciju proizvodnje Imunološkog zavoda za osiguranje samodostatnosti u proizvodnji krvnih pripravaka i lijekova dobivenih iz krvne plazme

Vlada Republike Hrvatske usvojila je dana 2. lipnja 2021. godine Zaključak o prihvaćanju Okvira i smjernica Plana provedbe revitalizacije proizvodnje Imunološkog zavoda

U srpnju 2021. godine Vijeće Europske unije usvojilo je Nacionalni plan oporavka i otpornosti 2021 – 2026

Vlada Republike Hrvatske na svojoj je sjednici održanoj 9. rujna 2021. godine donijela Uredbu o izmjenama i dopunama Uredbe o osnivanju Imunološkog zavoda („Narodne novine“ broj 99/2021)

Vlada Republike Hrvatske donijela je dana 30. prosinca 2021. godine Odluku o donošenju Nacionalnog plana razvoja zdravstva za razdoblje od 2021. do 2027. godine i Akcijskog plana razvoja zdravstva za razdoblje od 2021. do 2025. godine („Narodne novine“ broj 147/2021), uključivo aktivnosti vezane uz revitalizaciju Imunološkog zavoda

Vlada Republike Hrvatske usvojila je dana 23. ožujka 2022. godine Zaključak o prihvaćanju Okvira i smjernica Plana provedbe revitalizacije proizvodnje Imunološkog zavoda

Vlada Republike Hrvatske donijela je dana 21. lipnja 2023. godine Uredbu o izmjenama i dopunama Uredbe o osnivanju Imunološkog zavoda („Narodne novine“ broj 68/2023)

Program Vlade Republike Hrvatske za mandat 2024 – 2028

Vlada Republike Hrvatske donijela je dana 11. siječnja 2024. godine Odluku o donošenju Nacionalnog programa opskrbe Republike Hrvatske lijekovima proizvedenim iz ljudske plazme 2024 – 2027 („Narodne novine“ broj 5/2024)

Vlada Republike Hrvatske donijela je dana 20. svibnja 2024. godine Odluku o davanju suglasnosti Ministarstvu zdravstva, Imunološkom zavodu za preuzimanje obveza na teret sredstava državnog proračuna Republike Hrvatske u 2025. godini za sklapanje ugovora o javnoj nabavi za projektiranje i izgradnju postrojenja za proizvodnju zmijskog antitoksina (4.882.500,00 eura na lokaciji radna zona Rugvica-sjever, Općina Rugvica).

DOKUMENTACIJA

01.2024 VRH NACIONALNI-PROGRAM-OPSKRBE-REPUBLIKE-HRVATSKE-LIJEKOVIMA