Activities of the Institute of Immunology

The manufacture of immunological medicinal products, medicinal products derived from human blood or human plasma and other biological medicinal products is the main activity of the Institute of Immunology.

The Institute of Immunology has a long-standing tradition in the development and production of  viral  vaccines, including vaccines that were used in national  vaccination programs in the Republic of Croatia. The Edmonston-Zagreb measles virus vaccine strain and the rubella virus vaccine strain developed at the Institute of Immunology, were used in international  vaccination programs in numerous countries. Such programs have contributed to the successful control of diseases such as measles, rubella and mumps, in accordance with the recommendations of competent health institutions. The use of vaccines and the results of vaccination are subject to continuous monitoring and evaluation by competent health institutions.

Successful clinical use for half a century, and the absence of complications during use, place the European Viper Venom Antiserum (Equine) among the best products of its kind in the world. The use of European Viper Venom Antiserum (Equine) produced by the Institute of Immunology provides safety and effective protection from the snake – bite envenoming of bites from European snakes from the snake – bite envenoming by European snakes from the family Viperidae (genus Vipera).

More than half a century ago, the Institute of Immunology began manufacturing medicinal products derived from human blood or human plasma. The Institute of Immunology produces blood derivatives exclusively from plasma collected in the Republic of Croatia in full accordance with the Council of Europe, Recommendation – Rec(2002)11, which states that plasma of its own origin intended for its own population are also the best solution.

The Institute’s activities are:

  • manufacture of immunological medicinal products, medicinal products derived from human blood or human plasma and other biological medicinal products;
  • manufacture of active pharmaceutical ingredients intended for the production of biological medicinal products;
  • manufacture of medical devices;
  • wholesale distribution of medicinal products and medical devices;
  • scientific research and development activities in the field of biomedicine;
  • education in the field of manufacture and quality control of biological medicinal products;
  • clinical trials and mediation in clinical trials;
  • consulting services related to the activities of the Institute of Immunology.
    • The Institute of Immunology may also perform other activities that serve to the performance of the main activities, if they are performed on a smaller scale or are usually performed in addition to the activities of the Institute of Immunology, such as:
  • storage and keeping of MASTER SEEDS OF VIRUS STRAINS (Master seed of measles virus, Master seed of rubella virus, Master seed of mumps virus),
  • quality control testing of medicinal products.

Note: The Institute of Immunology is working intensively on revitalizing its manufacturing operations. In the meantime, our products will not be available (animal blood, animal blood – derived products, vaccines, medicinal products derived from human plasma).

STORAGE AND KEEPING OF MASTER SEEDS OF VIRUS STRAINS

Storage and keeping of master seeds of measles, mumps and rubella vaccine virus strains, owned by the Republic of Croatia, are performed at the Institute of Immunology.

The Institute of Immunology stores also working seeds of viruses, master and working cell banks of MRC-5 cells, intermediate products, historical samples and development materials.

Activities

MANUFACTURE OF BIOLOGICAL MEDICINAL PRODUCTS

Manufacture of biological medicinal products, including medicinal products derived from human blood or human plasma and other biological medicinal products.

QUALITY CONTROL OF MEDICINAL PRODUCTS

Quality control and testing of biological medicinal products.

WHOLESALE DISTRIBUTION

Wholesale distribution of medicinal products and medical devices.

SCIENTIFIC RESEARCH AND DEVELOPMENT

Takes place within the Research and Development Division in the field of biomedicine.

EDUCATION OF PROFESSIONAL TRAINING

Education and professional training in the field of manufacture and quality control of biological medicinal products.

VETERINARY MEDICINE

Professional activities related to the care and welfare of animals used for scientific purposes and manufacture of biological medicinal products.

ACTIVITIES

Zavod može obavljati i druge djelatnosti koje služe obavljanju glavnih djelatnosti, ako se one u manjem opsegu ili uobičajeno obavljaju uz djelatnost Zavoda, kao što je ostava i čuvanje matičnih sojeva virusa, te provjera kakvoće lijekova.

BIOLOGICAL MEDICINAL PRODUCTS

A biological medicinal product is a medicinal product whose active substance is a biological substance; a biological substance is a substance that is produced or extracted from a biological source and characterization and determination of its quality, physicochemical and biological tests are required, together with data on the manufacturing process and its control.

Biological medicinal products are considered to be immunological medicinal products, medicinal products derived from human blood or human plasma, medicinal products produced by biotechnological processes and medicinal products for advanced therapy.

IMMUNOLOGICAL MEDICINAL PRODUCTS

Immunological medicinal products are vaccines, toxins, sera and allergen products.

MEDICINAL PRODUCTS DERIVED FROM HUMAN BLOOD OR HUMAN PLASMA

A medicinal product derived from human blood or human plasma is an industrially manufactured medicinal product, which is based on blood components such as: albumin, coagulation factors and immunoglobulins of human origin, taking into account the principle of self-sufficiency in the supply of these medicinal products.